diff --git a/tools/perf/Makefile.config b/tools/perf/Makefile.config
index c896babf7a740e2bb4fb2c50a4a9f9f6998ee315..524a68032bdbebfb21a2caae30f90e75b15a575f 100644
--- a/tools/perf/Makefile.config
+++ b/tools/perf/Makefile.config
@@ -296,6 +296,11 @@ endif
 
 ifdef PYTHON_CONFIG
   PYTHON_EMBED_LDOPTS := $(shell $(PYTHON_CONFIG_SQ) $(PYTHON_CONFIG_LDFLAGS) 2>/dev/null)
+  # Update the python flags for cross compilation
+  ifdef CROSS_COMPILE
+    PYTHON_NATIVE := $(shell echo $(PYTHON_EMBED_LDOPTS) | sed 's/\(-L.*\/\)\(.*-linux-gnu\).*/\2/')
+    PYTHON_EMBED_LDOPTS := $(subst $(PYTHON_NATIVE),$(shell $(CC) -dumpmachine),$(PYTHON_EMBED_LDOPTS))
+  endif
   PYTHON_EMBED_LDFLAGS := $(call strip-libs,$(PYTHON_EMBED_LDOPTS))
   PYTHON_EMBED_LIBADD := $(call grep-libs,$(PYTHON_EMBED_LDOPTS)) -lutil
   PYTHON_EMBED_CCOPTS := $(shell $(PYTHON_CONFIG_SQ) --includes 2>/dev/null)
@@ -897,6 +902,9 @@ else
          PYTHON_SETUPTOOLS_INSTALLED := $(shell $(PYTHON) -c 'import setuptools;' 2> /dev/null && echo "yes" || echo "no")
          ifeq ($(PYTHON_SETUPTOOLS_INSTALLED), yes)
            PYTHON_EXTENSION_SUFFIX := $(shell $(PYTHON) -c 'from importlib import machinery; print(machinery.EXTENSION_SUFFIXES[0])')
+           ifdef CROSS_COMPILE
+             PYTHON_EXTENSION_SUFFIX := $(subst $(PYTHON_NATIVE),$(shell $(CC) -dumpmachine),$(PYTHON_EXTENSION_SUFFIX))
+           endif
            LANG_BINDINGS += $(obj-perf)python/perf$(PYTHON_EXTENSION_SUFFIX)
 	 else
            $(warning Missing python setuptools, the python binding won't be built, please install python3-setuptools or equivalent)